Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell
Mesoporous nanomaterials showed potential application in drug delivery,but non-specific leakage and multi-drug resistance seriously restricted the efficacy of chemotherapy.Based on the synthesis of mesoporous poly-dopamine(MPDA),pH/photothermal dual-responsive MPDA-DOX@PCM delivery nanosystem was constructed by loading chemotherapy drug doxorubicin(DOX)and coating phase-change material(PCM)1-tetradecanol,by which the photothermal therapy(PTT)and chemotherapy were achieved towards drug-resistant bladder cancer cell(BIU-87/ADR).The results indicated that the size of MPDA-DOX@PCM was about 179 nm,the max loading rate of DOX was 22％,and the photothermal conversion efficiency was up to 49.1％.Under the conditions of pH=7.4 and 25 ℃,the accumulative release rate of DOX was 4.57％,but can increase to 60.13％with the conditions of pH=5.5 and 45 ℃.Under the irradiation of 808 nm laser,the viability of BIU-87/ADR cells incubated with MPDA-DOX@PCM decreased to 9.5％,demonstrating the excellent combination performance of PTT/chemotherapy.
mesoporous polydopaminedrug deliverydual-responsecombination therapybladder cancer cell
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