Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells
Hollow copper sulfide(H-Cu2_xS)nanoparticles were developed and multifunctional nanoagent(PpIX@H-Cu2-xS)was obtained by loading sonosensitizers protoporphyrin(PpIX)in their cavity structures.H-Cu2-xS had a good photothermal conversion effect under near-infrared(NIR)light irradiation conditions and had a large specific sur-face area(68 m2·g-1),which could realize efficient loading of sonosensitizers PpIX.Under ultrasonic(US)excitation conditions(10 min),it was found that 46.1％of 1,3-diphenylisobenzofuran(DPBF)was oxidized by reactive oxygen species(ROS)produced by PpIX@H-Cu2-xS.In vitro cell experiments,PpIX@H-Cu2-xS had shown good biosafety and could effectively kill tumor cells under NIR/US excitation conditions.
hollow copper sulfideprotoporphyrinphotothermal therapysonodynamic therapyreactive oxygen species
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