无机化学学报2024,Vol.40Issue(10) :1919-1931.DOI:10.11862/CJIC.20240094

锰、铋共掺杂铌酸钠压电效应促进细胞增殖及抗菌

Piezoelectric effect of Mn,Bi co-doped sodium niobate for promoting cell proliferation and bacteriostasis

王世鹏 解尚谕 梁露娴 王雪红 魏杰 王德强
无机化学学报2024,Vol.40Issue(10) :1919-1931.DOI:10.11862/CJIC.20240094

锰、铋共掺杂铌酸钠压电效应促进细胞增殖及抗菌

Piezoelectric effect of Mn,Bi co-doped sodium niobate for promoting cell proliferation and bacteriostasis

王世鹏 1解尚谕 1梁露娴 1王雪红 1魏杰 1王德强1
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作者信息

  • 1. 华东理工大学材料科学与工程学院,上海 200237
  • 折叠

摘要

通过水热法制备了锰、铋共掺杂铌酸钠压电骨修复材料.通过扫描电镜、X射线衍射仪、X射线光电子能谱仪、压电力显微镜、电化学工作站、紫外可见近红外光谱仪、电子顺磁共振波谱仪等对该材料的微观形貌、组成结构、压电性能、声动力性能和类酶活性等进行表征.结果表明,该材料兼具压电性能和类酶活性,超声触发压电响应不仅促进细胞增殖,而且增强声动力和类酶活性,产生活性氧,协同杀死细菌/清除生物膜.

Abstract

A bone repair material of Mn,Bi co-doped sodium niobate with piezoelectricity was prepared using the hydrothermal method.The microscopic morphology,composition,piezoelectricity,sonodynamic and enzyme-like activity of the material was characterized by scanning electron microscope,X-ray diffractometer,X-ray photoelec-tron spectrometer,piezoelectric force microscope,electrochemical workstation,ultraviolet-visible-near-infrared spectrometer,and electron paramagnetic resonance spectrometer.The results demonstrate that the material possess-es both piezoelectric properties and enzyme-like activity;the ultrasound-triggered piezoelectric effect not only pro-motes cell proliferation but also enhances sonodynamic and enzyme-like activity,which generates reactive oxygen species for synergistic killing of bacteria/removal of biofilm.

关键词

压电效应/声动力/类酶活性/细胞增殖/抗菌

Key words

piezoelectricity/sonodynamic/enzyme-like activity/cell proliferation/antibacterial

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基金项目

国家自然科学基金(32171340)

出版年

2024
无机化学学报
中国化学会

无机化学学报

CSTPCD北大核心
影响因子:0.665
ISSN:1001-4861
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