High sensitivity detection of baicalein by N,S co-doped carbon dots and their application in biofluids
In this work,p-phenylenediamine and L-cysteine were used as raw materials,and water-soluble N,S co-doped carbon dots(N,S-CDs)with excellent performance were prepared through a one-step solvothermal method.The morphology and structure of N,S-CDs were characterized by transmission electron microscope,X-ray diffrac-tion,Fourier transform infrared spectroscopy,and X-ray photoelectron spectroscopy,and the basic photophysical properties were investigated via UV-Vis absorption spectra and fluorescence spectra.Meanwhile,the N,S-CDs have excellent luminescence stability with pH,ionic strength,radiation time,and storage time.Experimental results illus-trated the present sensor platform exhibited high sensitivity and selectivity in response to baicalein with a detection limit of 85 nmol·L-1.The quenching mechanism is proved to be the inner filter effect.In addition,this sensor can also detect baicalein in biofluids(serum and urine)with good accuracy and reproducibility.
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