Research advances of atomic precision coinage metal nanoclusters in tumor therapy
Malignant tumors are one of the most serious threats to human health,and it has been a wildly discussed topic to establish efficient and accurate tumor treatment techniques.With the rapid development of nanomedicine technology,nanomaterial-mediated tumor treatment techniques have attracted more attention due to their low inva-siveness,high specificity,and good therapeutic effects.As a new member of the nanomaterial family,atomically pre-cise coinage metal nanoclusters show great potential in tumor treatment due to their excellent biocompatibility,sur-face modifiability,good optical properties,and efficient catalytic activity(generation of reactive oxygen species).This review mainly discusses the progress of research on atomically precise coinage metal nanoclusters in tumor treatment.Their antitumor mechanism is detailed in different therapies(radiation therapy,photothermal therapy,photodynamic therapy,chemodynamic therapy,drug delivery,and multimodal combination therapy).Moreover,the current challenges and prospects of metal nanoclusters in antitumors are summarized.
atomically precisecoinage metal nanoclustertumortherapy