Research progress of formation mechanism and characterization techniques of protein corona on the surface of nanoparticles
In biological fluids,proteins bind to the surface of nanoparticles to form a coating named the protein coro-na,which can dramatically change their physicochemical properties and affect interactions with living systems.Understanding the formation mechanism and dynamic changes of protein corona can help optimize the design of nanoparticles,improve the targeting and effectiveness of nanomedicines,and reduce side effects.In this review,we first reviewed the progress of protein corona and highlighted the properties of protein corona,the factors influencing their formation,and the analytical techniques for probing the protein corona.Finally,we share our perspective on the challenges and opportunities of protein corona in characterization methods and controlling their formation and composition.This review will contribute to understanding protein corona for the development and application of nanomedicine and biotechnology.
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