To study the synthesis and antitumor activities of the transition metal complexes incorporating a novel naphthol-aldehyde Schiff base ligand,three transition metal complexes[Cu(L)2(DMF)2](1),[Ni(L)2(DMF)2](2),and[Zn(L)2](3)were synthesized using a Schiff base of N-[(2-hydroxy-1-naphthalenyl)methylene]-[(1H-indol-3-yl)ethyl]imine(HL)by liquid diffusion method.The complexes 1-3 were characterized by IR analysis,elemental analysis,and single-crystal X-ray diffraction.Moreover,their antitumor activities in vitro were screened through three human cancer cell lines(MGC-803,A549,MDA-MB-231)by the MTT assay.It revealed that complexes 1-3 showed high antitumor activities.Complex 1 showed much higher antitumor activities than complexes 2 and 3,and even than cis-platin.Among them,complex 1 had the highest inhibitory effects on tumor cells with its IC50 value(half-inhibitory concentration)being(4.8±0.2)μmol·L-1 against MGC-803 cells.These demonstrated a potential anti-cancer candi-date for complex 1,which induced MGC-803 cancer cells'late apoptosis by flow cytometry.Subsequently,the cell scraper experiment showed that the killing effect of MGC-803 cells was enhanced with the increase in the concentra-tion of complex 1.CCDC:2354708,2;2354849,3.
关键词
萘酚醛席夫碱/过渡金属配合物/合成/晶体结构/抗肿瘤活性
Key words
naphthol-aldehyde Schiff base/transition metal complex/synthesis/crystal structure/antitumor activity
维普
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