Multifunctional nanozyme Prussian blue modified copper peroxide:Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide
A multifunctional nanomaterial CuO2/PB with H2O2 self-supply and photothermal-enhanced enzyme-like activity was obtained by introducing CuO2 into Prussian blue(PB).The simulated tumor microenvironment(TME)can produce H2O2 and consume glutathione(GSH),further enhancing the generation of·OH and the consumption of GSH with near-infrared light irradiation.In addition,mouse experiments have shown that CuO2/PB can be used for T2-magnetic resonance imaging-guided tumor therapy.In the 14 d treatment cycle,combined with near-infrared light irradiation,it had a significant inhibitory effect on tumors,achieving photothermal therapy combined with H2O2 self-supply catalytic therapy,which provides a new idea for improving the efficiency of catalytic treatment.
万方数据
维普
