首页|Potential impact of specific therapy on pregnant women with pulmonary arterial hypertension without cardiac shunt:a descriptive study in northern China

Potential impact of specific therapy on pregnant women with pulmonary arterial hypertension without cardiac shunt:a descriptive study in northern China

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Background:Pregnancy in women with pulmonary arterial hypertension(PAH)is a fatal condition,despite the effectiveness of PAH-specific therapies.The coverage status and effect of specific therapies in pregnant patients with PAH without cardiac shunts in China remain unclear.To investigate this issue,we conducted a multicenter retrospective study in northern China.Methods:The study included 85 patients who were admitted to 4 clinical centers in Shandong Province between October 2010 and August 2020.Maternal endpoint events included(1)maternal death and/or(2)major adverse cardiac events,both occurring during preg-nancy or within 6 weeks postpartum.Results:Although the overall mortality rate was encouraging(11.8％),the number of patients receiving PAH-specific therapies was ex-tremely low(28.2％).Moreover,only 15.3％of patients received adequate duration of PAH-specific therapy(≥4 weeks)before delivery,and this subgroup showed the lowest major adverse cardiac events rate(7.7％)compared with that in the untreated(19.7％)and short-time treated groups(＜4 weeks;54.5％).Conclusion:Pregnant patients with PAH without cardiac shunts face significantly increased mortality risks.Short-term PAH-specific therapy does not guarantee favorable maternal outcomes.Prepregnancy screening,early identification,and timely intervention are ex-pected to improve maternal outcomes in pregnant women with PAH.

Major adverse cardiac eventsMaternal mortalityPregnancy outcomePulmonary arterial hypertensionSpecific therapy

Weida Lu、Min Li、Fuqing Ji、Hua Feng、Guo Li、Qiushang Ji、Hongyu Zhang、Xiaopei Cui

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Department of Geriatric Medicine & Shandong Key Laboratory Cardiovascular Proteomics,Qilu Hospital of Shandong University,Jinan,Shandong,China

Intensive Care Unit of Cardiac Surgery,Shandong Provincial Qianfoshan Hospital,the First Hospital Affiliated with Shandong First Medical University,Affiliated Hospital of Shandong University,Jinan,Shandong,China

Department of Cardiology,Linyi Central Hospital,Linyi,Shandong,China

Department of Gastroenterology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong,China

Department of Pulmonary and Critical Care Medicine,the Affiliated Hospital of Qingdao University,Qingdao,Shandong,China

Department of Cardiology,Qilu Hospital of Shandong University,Jinan,Shandong,China

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Shandong Provincial Natural Science FoundationShandong Provincial Natural Science FoundationDoctoral Program of Shandong Provincial Natural Science Foundation

ZR2021MH111 for Cui XZR2020MH033 for Zhang HZR2017BH047 for Lu W

2024

10.1097/EC9.0000000000000103

急危重症医学(英文)

急危重症医学(英文)

ISSN：
年,卷(期)：2024.4(2)
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