Correlation of plasma Ang Ⅱ,TGF-β1 and BNP levels with cardiac function and pulmonary arterial hypertension in patients with pulmonary heart disease
Objective:To investigate the correlation of plasma angiotensin Ⅱ(Ang Ⅱ),transforming growth factor-beta1(TGF-β1)and brain natriuretic peptide(BNP)levels with cardiac function and pulmonary arterial hypertension in patients with pulmonary heart disease.Methods:Ninety patients diagnosed with pulmonary heart disease in our hospital were included from January 2021 to January 2023 in the observational group,and 125 healthy subjects undergoing physical examination in our hospital during the same period were recruited as controls(control group).Morning fasting blood samples were harvested from the subjects in both groups,and determined for plasma BNP level using immunofluorescence assay,and Ang Ⅱ and TGF-β1 levels using enzyme-linked immunosorbent assay.Results:The plasma Ang Ⅱ,TGF-β1 and BNP levels were significantly higher in patients in the observational group than those in the control group(P＜0.05),and the plasma Ang Ⅱ,TGF-β1 and BNP levels were escalated in patients with higher cardiac functional grading(P＜0.05).Correlation analysis demonstrated that the cardiac functional grade was positively related to plasma Ang Ⅱ,TGF-β1 and BNP levels(P＜0.05).The higher of the pulmonary arterial pressure was,the higher plasma Ang Ⅱ,TGF-β1 and BNP levels would be in the patients(P＜0.05),and correlation analysis indicated positive correlation of pulmonary arterial pressure with plasma Ang Ⅱ,TGF-β1 and BNP levels(P＜0.05).Conclusion:The plasma Ang Ⅱ,TGF-β1 and BNP levels are positively correlated with cardiac functional grading and pulmonary arterial pressure in patients with pulmonary heart disease,and the cardiac function would be poorer and pulmonary arterial pressure would be severe with added Ang Ⅱ,TGF-β1 and BNP levels.
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