Correlation between abdominal fat content and bone mineral density in patients with type 2 diabetes mellitus:Quantitative CT-based analysis
Objective:To apply quantitative computed tomography(QCT)to investigating the correlation between abdominal fat content and bone mineral density(BMD)in patients with type 2 diabetes(T2DM).Methods:Retrospective analysis was performed in 268 patients with clinically confirmed T2DM in our hospital between July 2019 and November 2022.The clinical data,including patients'gender,age,duration of disease,body mass index(BMI),urinary albumin-to-creatinine ratio(UACR),and glycosylated hemoglobin(HbA1c)were statistically collected.By the clinical recommendations of American Diabetes Association(ADA)for prevention and control of diabetic nephropathy,the diabetic patients were then divided into group A(no presence of proteinuria,n=123 cases),group B(with micro-proteinuria present,n=84 cases),and group C(with massive proteinuria present,n=61 cases)according to UACR.QCT was applied to determine the level of visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT)at the level of L3 as well as the average bone mineral density(avBMD)at the L1-2.One-way analysis of variance(ANOVA)or rank sum test was used to compare the variability of each parameter between groups,and Pearson correlation was used to analyze the correlation between BMD and VAT.Results:VAT content was sequentially increased in the T2DM patients in the three groups,whereas BMD level was all successively decreased,with statistical difference(P＜0.05).Correlation analysis showed that BMD was negatively correlated with VAT content in T2DM patients(r=-0.496,P＜0.001).Conclusion:Quantitative CT can demonstrate the changes in abdominal fat distribution and BMD in patients with T2DM.The findings suggest that quantitative CT can provide a reference basis for early prevention of nephropathy and estimation of development of T2DM.
quantitative CTtype 2 diabetes mellitusvisceral adipositysubcutaneous adipositybone mineral density
万方数据
维普
