Objective:To observe the clinical efficacy of individualized disease perception management combined with preemptive analgesia for patients with massive rotator cuff injuries.Methods:Fifty-two patients with massive rotator cuff tear undergone arthroscopic repair in our hospital were included from June 2020 to April 2022.Patients treated during June 2020 and April 2021 were allocated to control group(n=26),and those treated between May 2021 and April 2022 were included in observational group(n=26).Patients in control group just received conventional care,and those in the study group were given individualized disease perception management plus preemptive analgesia.The two groups were compared regarding the compliance with postoperative functional exercise,scores on Constant-Murley Scale for shoulder function,Visual Analogue Scale(VAS),Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)before and after operation to evaluate the efficacy.Results:Postoperative functional exercise compliance was higher in the observational group than in the control group(P<0.05).The scores on Constant-Murley Scale were higher,yet the scores on SAS and SDS were lower at the 6th month after surgery compared to those before operation(P<0.05).Improvement in the scoring on SAS and SDS was better in the observational group than in control group by the 6th month following surgery(P<0.05).The decrease on VAS was significant in both groups,yet was more notable in the observational group than in the control group at the 3rd week and 6th month compared to pre-operation(P<0.05).Conclusion:Individualized disease perception management plus preemptive analgesia applied for the patients with massive rotator cuff injuries following surgery can improve the compliance with postoperative functional exercise and shoulder function,reduce anxiety,depression and pain,and promote early recovery of this group of patients.