Objective:To investigate the predictive value of neutrophil to lymphocyte ratio(NLR)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A retrospective analysis was performed in AECOPD patients,admitted to and treated in our hospital between January 2019 and August 2022,and healthy subjects undergoing physical examination during the same period were enrolled as controls.NLR was calculated based on neutrophil(NEU)and lymphocyte(LYM)counts obtained during laboratory tests.Results:NLR levels in AECOPD group were significantly increased than those in control group(P＜0.05).NLR was positively correlated with CRP and length of hospital stay(rs=0.564 and 0.304 respectively,P＜0.05).Compared with AECOPD patients undergoing oxygen inhalation,the NLR level of those undergoing noninvasive mechanical ventilation was significantly increased,and the NLR and CRP levels of those undergoing invasive mechanical ventilation were significantly increased(P＜0.05).ROC curve analysis showed that the area under ROC curve of NLR level predicting the need for mechanical ventilation in AECOPD patients was 0.761,with a cutoff value of 5.83,sensitivity of 86.9％and specificity of 54％.The area under ROC curve of NLR level predicting the death of AECOPD patients undergoing mechanical ventilation was 0.731,with a cutoff value of 8.73,sensitivity of 94.1％and specificity of 42.2％.Conclusion:NLR can be used as a prognostic indicator for AECOPD patients.
关键词
慢性阻塞性肺疾病/中性粒细胞/淋巴细胞比值/机械通气
Key words
chronic obstructive pulmonary disease/neutrophil to lymphocyte ratio/mechanical ventilation
维普
万方数据