Quantitative CT analysis of the correlation between abdominal fat and metabolic syndrome in different genders
Objective:To investigate the correlation between abdominal fat and metabolic syndrome(MS)in different genders based on Quantitative CT(QCT).Methods:In total,1612 subjects undergoing bone density examination by QCT in our hospital were recruited from March 2022 to May 2023,and divided into MS group(314 males and 122 females)and non-MS group(704 males and 472 females).QCT was used to obtain fat parameters at lumbar-3 vertebral level in two groups,including total fat area(TFA),visceral fat area(VFA),subcutaneous fat area(SFA),and subcutaneous/visceral fat area ratio(SVR),representing total abdominal fat,visceral fat,subcutaneous fat and fat distribution respectively.Multivariate logistic regression model was employed to determine the independent factors affecting the fat parameters in MS,and receiver operating characteristic(ROC)curve was generated.Results:The TFA and VFA in males were higher than those in females(P＜O.001),while the SFA and SVR in males were lower(P＜0.001).The TFA,VFA and SFA of both genders in the MS group were higher than those in the non-MS group,whereas the SVR was lower than that in the non-MS group(P＜0.01).Among males,elevated TFA and VFA were independent risk factors for MS(P＜0.05),elevated SVR was an independent protective factor for MS(P＜0.05),and the AUC(0.851)of VFA for diagnosing MS was the highest.Among females,elevated TFA,VFA and SFA were independent risk factors for MS(P＜0.05),and the AUC(0.850)of VFA for diagnosing MS was the highest.Conclusion:There are certain gender differences in the relationship between abdominal fat and MS.Total abdominal fat and visceral fat in both genders and subcutaneous fat in females are independent risk factors for MS.SVR in males is an independent protective factor for MS.QCT can be used for screening MS patients.
万方数据
维普
