Effect of dapagliflozin on epicardial adipose tissue volume in patients with type 2 diabetes mellitus
Objective:To observe the effect of dapagliflozin(DAP)on the volume of epicardial adipose tissue(EAT)in patients with type 2 diabetes mellitus(T2DM),and analyze the correlation of EAT volume with serum interleukin-6(IL-6)and adiponectin(ADPN)levels.Methods:EAT volume was determined in 32 T2DM patients without DAP therapy(control group)and 30 T2DM patients treated with DAP(DAP group).Clinical data were collected,and serum levels of IL-6 and ADPN were determined in the patients in both groups.Pearson correlation was used to analyze the association between EAT volume and serum IL-6 and ADPN levels.Results:Compared with the control group,the EAT volume and serum IL-6 levels were significantly reduced in T2DM patients treated with DAP(P<0.01),whereas ADPN level was increased(P<0.01).Furthermore,EAT volume was positively correlated with serum IL-6 content in T2DM patients(r=0.509,P<0.01),yet negatively with serum ADPN level(r=-0.432,P<0.01).Conclusion:DAP treatment may reduce EAT volume in patients with T2DM,which can contribute to minimizing the risk of cardiovascular events.
type 2 diabetes mellitusdapagliflozinepicardial adipose tissue volume
万方数据
维普
