术前血清PCSK9检测联合甘油三酯-葡萄糖指数、甘油三酯-高密度脂蛋白胆固醇比值对乳腺癌患者的临床应用价值

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中文摘要：目的:探讨术前血清前蛋白转化酶枯草溶菌素9(PCSK9)检测联合甘油三酯-葡萄糖指数(TyG)、甘油三酯-高密度脂蛋白胆固醇比值(TG/HDL-c)对乳腺癌患者的临床意义.方法:收集蚌埠医科大学第一附属医院经病理确诊并手术治疗的乳腺癌患者122 例,行手术切除的乳腺良性肿瘤患者76 例,健康体检者 105 例,统计分析各组患者完整的病历资料,利用ROC曲线确定血清PCSK9、TyG及TG/HDL-c的最佳临界值,并分析其对乳腺癌患者预后的临床价值.结果:良性肿瘤组和健康对照组血清PCSK9、TyG及TG/HDL-c水平低于乳腺癌组(P<0.05);矫正多因素Logistic回归分析显示,血清TyG(OR=2.766,95%CI:1.449～5.278)、TG/HDL-c(OR=28.624,95%CI:5.055～162.094)及PCSK9(OR=1.082,95%CI:1.060～1.105)水平升高均为乳腺癌发生的危险因素(P<0.001).ROC曲线评估显示,血清PCSK9、TyG和TG/HDL-c联合分析(AUC=0.905)诊断效能高于TyG(AUC=0.797)和TG/HDL-c(AUC=0.713),P<0.01.结论:血清PCSK9、TyG和TG/HDL-c可作为乳腺癌患者辅助性诊断指标.

外文标题：Clinical value of preoperative serum PCSK9 detection combined with TyG index and TG/HDL-c ratio in patients with breast cancer

外文摘要：Objective:To investigate the clinical value of preoperative serum protein convertase subtilisin/kexin type 9(PCSK9)detection combined with triglyceride-glucose(TyG)index and triglyceride-high-density lipoprotein cholesterol(TG/HDL-c)ratio in patients with breast cancer.Methods:The complete medical records were obtained from 122 cases of breast cancer confirmed by pathology and treated surgically,76 cases of benign breast tumors removed surgically,and 105 cases of healthy subjects undergoing physical examination in our hospital.The data in each group were statistically analyzed.ROC curve was used to determine the optimal threshold of serum PCSK9,TyG and TG/HDL-c,and their clinical value in predicting the prognosis of breast cancer patients was analyzed.Results:The serum levels of PCSK9,TyG index and TG/HDL-c ratio in benign tumor group and healthy control group were significantly lower than those in breast cancer group(P<0.05).The corrected multivariate logistic regression analysis showed that elevated serum TyG index(OR=2.766,95%CI:1.449-5.278),TG/HDL-c ratio(OR=28.624,95%CI:5.055-162.094)and PCSK9 level(OR=1.082,95%CI:1.060-1.105)were all risk factors for breast cancer(P<0.001).The ROC curve showed that combined analysis of serum PCSK9,TyG index and TG/HDL-c ratio(AUC=0.905)had significantly higher diagnostic accuracy than TyG index(AUC=0.797)and TG/HDL-c ratio(AUC=0.713)alone(P<0.01).Conclusion:Serum PCSK9,TyG index and TG/HDL-c ratio can serve as auxiliary diagnostic indicators for breast cancer patients.High levels of serum PCSK9,TyG and TG/HDL-c indicate poor prognosis for patients.

外文关键词：

serum protein convertase subtilisin/kexin type 9triglyceride-glucose indextriglyceride-high-density lipoprotein cholesterol ratiobreast cancer

作者：

郭晖、王月月、李竟、曹通、王凤超

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作者单位：

蚌埠医科大学第一附属医院检验科,安徽蚌埠 233004

关键词：

血清前蛋白转化酶枯草溶菌素9 甘油三酯-葡萄糖指数甘油三酯-高密度脂蛋白胆固醇比值乳腺癌

基金：

蚌埠医科大学自然科学重点项目安徽省自然科学基金

项目编号：

2021byzd1532008085QH404

出版年：

2024

DOI：

10.3969/j.issn.1002-0217.2024.03.008

皖南医学院学报

皖南医学院

皖南医学院学报

CSTPCD

影响因子：0.695

ISSN：1002-0217

年,卷(期)：2024.43(3)