Objective:To investigate the clinical value of preoperative serum protein convertase subtilisin/kexin type 9(PCSK9)detection combined with triglyceride-glucose(TyG)index and triglyceride-high-density lipoprotein cholesterol(TG/HDL-c)ratio in patients with breast cancer.Methods:The complete medical records were obtained from 122 cases of breast cancer confirmed by pathology and treated surgically,76 cases of benign breast tumors removed surgically,and 105 cases of healthy subjects undergoing physical examination in our hospital.The data in each group were statistically analyzed.ROC curve was used to determine the optimal threshold of serum PCSK9,TyG and TG/HDL-c,and their clinical value in predicting the prognosis of breast cancer patients was analyzed.Results:The serum levels of PCSK9,TyG index and TG/HDL-c ratio in benign tumor group and healthy control group were significantly lower than those in breast cancer group(P<0.05).The corrected multivariate logistic regression analysis showed that elevated serum TyG index(OR=2.766,95%CI:1.449-5.278),TG/HDL-c ratio(OR=28.624,95%CI:5.055-162.094)and PCSK9 level(OR=1.082,95%CI:1.060-1.105)were all risk factors for breast cancer(P<0.001).The ROC curve showed that combined analysis of serum PCSK9,TyG index and TG/HDL-c ratio(AUC=0.905)had significantly higher diagnostic accuracy than TyG index(AUC=0.797)and TG/HDL-c ratio(AUC=0.713)alone(P<0.01).Conclusion:Serum PCSK9,TyG index and TG/HDL-c ratio can serve as auxiliary diagnostic indicators for breast cancer patients.High levels of serum PCSK9,TyG and TG/HDL-c indicate poor prognosis for patients.
关键词
血清前蛋白转化酶枯草溶菌素9/甘油三酯-葡萄糖指数/甘油三酯-高密度脂蛋白胆固醇比值/乳腺癌
Key words
serum protein convertase subtilisin/kexin type 9/triglyceride-glucose index/triglyceride-high-density lipoprotein cholesterol ratio/breast cancer
维普
万方数据