Association of parathyroid hormone with protein-energy wasting in hemodialysis patients
Objective:To investigate the correlation between protein-energy wasting(PEW)and parathyroid hormone(PTH)level in patients undergoing maintenance hemodialysis(MHD).Methods:Clinical and anthropometric data were obtained in 102 patients undergoing MHD in the dialysis center of our hospital between January and December of 2021.PEW diagnostic criteria were established in compliance with the International Society of Renal Nutrition and Metabolism plus lean tissue index(LTI)and body cell mass index(BCMI).Then the patients were assigned to low PTH group(PTH<150 pg/mL),target PTH group(150≤PTH<600 pg/mL),high PTH group(600≤PTH<1 000 pg/mL)or extremely high PTH group(PTH≥1 000 pg/mL)by the determined PTH level.Logistic regression model was used to analyze the relationship between PTH level and the risks of PEW.Results:Incidence of PEW was 49%%(50/102)in the MHD patients.Several nutritional indicatorsin the low PTH group were lower than those in the target PTH group(P<0.05),and partial nutritional indicators of the extremely high PTH group were significantly lower than those of the PTH target group(P<0.05).Patientswith PEW were graded according to the MIS score.The results showed that severity of malnutrition differed greatly in patients among different PTH groups(P<0.05).Multivariate logistic regression analysis demonstrated that added age at dialysis and low PTH level were associated with the risks of PEW(P<0.05).Conclusion:The incidence of PEW appears relatively higher in MHD patients,and serum PTH level is related to the occurrence of PEW,which suggests that clinical attention should be paid to early prevention and treatment in such patients.
万方数据
维普
