Correlation between type 2 diabetic peripheral neuropathy and blood glucose fluctuation
Objective:To explore the correlation between type 2 diabetic peripheral neuropathy(DPN)and blood glucose fluctuation.Methods:112 type 2 diabetes mellitus patients with peripheral neuropathy were included,and divided into asymptomatic group(DPN1 group)and symptomatic group(DPN2 group).Then the two groups were compared pertinent to the gender,age,disease duration,biochemical indicators and blood glucose fluctuation indicators.Multivariate logistic regression model was used to analyze the relationship between DPN symptoms and blood glucose fluctuation indicators.Results:Patients in the DPN2 group had lower TG level,yet higher Cys-C level compared to those in the DPN1 group(P<0.05).The CV,SDBG,MAGE,TAR,TBR and MBG levels in the DPN2 group were higher than those in the DPN1 group,and the TIR level was lower than that in the DPN1 group(P<0.05).Multivariate logistic regression analysis showed that elevated Cys-C and CV were independent risk factors for DPN(P<0.05),and decreased TIR was a protective factor for DPN(P<0.05).Conclusion:With the same HbA1c levels,blood glucose fluctuation and elevated Cys-C are risk factors for DPN symptoms.
type 2 diabetesperipheral neuropathysymptomglycosylated hemoglobin A1cblood glucose fluctuation
万方数据
维普
