Animal experimentation on preventing bisphosphonate-related osteonecrosis of the jaw with parathyroid hormone
Objective:To investigate the effect of parathyroid hormone(PTH)on the development of bisphosphonate-related osteonecrosis of the jaw(BRONJ)in rat models.Methods:BRONJ-like disease was induced by tooth extraction stimulation in SD rats with long-term intraperitoneal injection of zoledronate(ZOL)and dexamethasone(DXMS).Then PTH was subcutaneously and prophylactically applied to the rats in treatment group,whereas rats in the experimental group and control group were in blank intervention.Results:BRONJ model was successfully established by combining zoledronate and dexamethasone under the stimulation of tooth extraction wound.The thickness,density and the number of trabeculae were decreased in rats in the experimental group,yet trabecular separation was increased compared with the blank group(all P<0.05).The thickness,density and the number of trabeculae were increased in rats in the treatment group,whereas trabecular separation was decreased compared to the experimental group(all P<0.05).Conclusion:The BRONJ rat model was successfully established,and parathyroid hormone was confirmed to inhibit the occurrence of BRONJ to a certain extent,and produce certain effect on the treatment of BRONJ.
bisphosphonate-related osteonecrosis of the jawanimal modelparathyroid hormone
万方数据
维普
