Associations of ALDH2 rs671 and ADH1B rs1229984 polymorphisms with gastric and esophageal cancer risks
Objective:To explore the associations of ADH1B rs1 229984 and ALDH2 rs671 polymorphisms with gastric and esophageal cancer risks.Methods:Using a random number table method,100 patients(50 with gastric cancer and 50 with esophageal cancer)treated at the Second People's Hospital of Lianyungang from January to December 2021 were randomly enrolled,along with 200 healthy Han ethnic blood donors serving as healthy group.The polymorphisms of ADH1B rs1229984 and ALDH2 rs671 SNPs were detected,and their associations with gastric cancer and esophageal cancer were investigated in the Han population in Lianyungang area.Results:Comparison of the general clinical data,including gender,age,BMI,smoking history and drinking history among the three groups of subjects showed no significant differences(P>0.05).In healthy group,the frequencies of rs1229984 AA,AG,and GG genotypes were 42.5%(85 cases),53.5%(107 cases),and 4%(8 cases),respectively.For rs671,the genotype frequencies were 1%(2 cases)for AA,26.5%(53 cases)for AG,and 72.5%(145 cases)for GG.Both sets of genotype frequencies complied with the Hardy-Weinberg equilibrium(P>0.05),indicating their representativeness in the population.The analysis results showed that the distribution frequencies of ALDH2 rs671 AA,AG and GG in gastric and esophageal cancer group patients were statistically different from those in healthy group patients(P<0.05).Significant differences were observed in the distribution frequencies of the ADH1B rs1229984 AA,AG and GG genotype,between esophageal cancer patients and healthy controls(P<0.05).Conclusion:The genetic distribution patterns in gastric cancer and esophageal cancer groups differ significantly from those in the healthy control group.The polymorphisms of ADH1B rs1229984 and ALDH2 rs671 have a certain association with gastric cancer and esophageal cancer in the Han population living in Lianyungang area.
rs1229984rs671polymorphismgastric canceresophageal cancer