Tumor-specific growth factors and severity of acute exacerbation of chronic obstructive pulmonary disease
Objective:To investigate the correlation between tumor-specific growth factor(TSGF)and the severity of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Retrospective analysis was conducted on the clinical data and laboratory findings in 100 patients with AECOPD.The cases were divided into non-severe group and severe group by the GOLD classification.The automatic biochemical analyzer 008 AS of HITACHI,automatic blood cell analyzerXN1001 and automatic blood coagulation analyzer CS-5100 of SYSMEX were used to detect serum TSGF,hypersensitive C-reactive protein(hs-CRP),D-Dimer(D-D),white blood cell(WBC)count,platelet count(PLT),neutrophil(N)count,red blood cell distribution width(RDW),lymphocyte(L)count and fibrinogen(FIB).Pearson and Spearman correlation was used to analyze the correlation of TSGF with NLR,hs-CRP,FIB and RDW,While logistic regression was performed to analyze the correlation between TSGF and other indicators and the severity of AECOPD,respectively.The predictive efficacy of TSGF in the diagnosis severity of AECOPD was evaluated by comparing the area under the curve(AUC)of ROC curve.Results:TSGF in patients of severe group was significantly higher than that in those of non-severe group(P<0.05),and positively correlated with hs-CRP,FIB and RDW(P<0.05).Higher TSGF was significantly correlated with severity of AECOPD(OR=1.391,95%CI:1.210-1.599,P<0.001);The area of ROC curve was 0.920 in predicting the severity of patient with AECOPD(95%CI:0.848~0.965,P<0.001)and the cut-off value of TSGF was 65.5,with sensitivity being 96%and specificity being 90%.Conclusion:TSGF may be a new biomarker to evaluate the severity of AECOPD.
tumor-specific growth factorratio of neutrophils to lymphocytesfibrinogenhypersensitive C-reactive proteinacute exacerbation of chronic obstructive pulmonary disease