Preliminary study on the dosimetry and toxicity of tumor bed boost in postoperative radiotherapy for cervical cancer with full-thickness stromal invasion
Objective:To preliminarily investigate the dosimetry and toxicity response of tumor bed boost in postoperative radiotherapy for cervical cancer with full-thickness stromal invasion.Methods:Aretrospective analysis was conducted in 15 patients with full-thickness stromal invasion suggested by postoperative pathology,who received tumor bed boost therapy in our hospital between May 2020 and August 2023.The dosimetry indexes of target areas and organs involved as well as toxicological reaction were analyzed before and after the application of tumor bed boost.Results:After boost irradiation to the tumor bed area,the minimum dose(Dmin),mean dose(Dmean),and maximum dose(Dmax)of the planning target volume of tumor bed(PGTVtb)were significantly higher than those before the boost(P＜0.05).V30,V40 and V50 of bladder and V40 and V50 of rectum were significantly increased compared to those before the boost(P＜0.05).There was no significant difference in V30,V40 and V50 of the small intestine(P＞0.05)and V40,V50 of the bilateral femoral heads before and after the boost(P＞0.05).After tumor bed boost therapy,patients experienced mild(grade 1 and 2)acute genitourinary and lower gastrointestinal adverse reactions.Nine(60.00％)and 5 patients(33.33％)respectively experienced moderate(grade 3)decreases in white blood cells and neutrophils,and another one experienced a grade 3 platelet decrease.No severe(grade 4)acute adverse reactions were observed.Conclusion:Tumor bed boost after cervical cancer surgery has potential clinical application value,for this therapy can increase the dose in the tumor bed area,with tolerable toxic and side effects.
cervical cancertumor bed boostradiotherapyinvolved organs
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