Clinical application of combined traditional Chinese and Western medicine treatment in chemotherapy-induced peripheral neurotoxicity
Objective:To investigate the efficacies of integrated traditional Chinese and Western medicine[oral vitamin B6,duloxetine and Huangqi Guizhi Wuwu Decoction(HGWD)combined with acupuncture]in the treatment of chemotherapy-induced peripheral neuropathy(CIPN).Methods:Thirty-three tumor patients with grade 3 CIPN in our hospital were included from May 2021 to October 2022,and integrally treated with oral vitamin B6,duloxetine,HGWD and acupuncture.The treatment efficacies were evaluated by the patents'Karnofsky Performance Status(KPS),and the scoring of the patients on self-care activities was compared to identify the clinical features that influenced the treatment outcome.Results:The response rate of combined traditional Chinese and Western medicine in the treatment of grade Ⅲ CIPN was 75.8％(25/33),and median time to onset of symptom relief was(14.96±1.00)days.The baseline KPS score in patients of the effective group was significantly higher before treatment than that of those of ineffective group(72.80±9.36 vs.61.25±3.54;P＜0.05).The KPS score was improved in 33 patients after treatment(83.64±8.22 vs.70.00±9.68;P＜0.001).Multivariate analysis showed that a high preoperative KPS score was a protective factor for effective treatment in such patients(P＜0.05).Conclusion:Integrated traditional Chinese and Western medicine regimen can produce a beneficial therapeutic effect on grade 3 CIPN,which may serve as a promising strategy in clinical practice.
integrated traditional Chinese and Western Medicinechemotherapyperipheral neurotoxicity
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