Clinical efficacy of sodium hyaluronate plus carbomer gel in treating ocular surface damage in TAO
Objective:To investigate the clinical efficacy of sodium hyaluronate eyedrops plus carbomer ophthalmic gel in treating thyroid-associated ophthalmopathy(TAO)with ocular surface damage.Methods:Thirty-four TAO patients(68 eyes)complicated with ocular surface damage admitted to our hospital were enrolled between March 2017 and May 2023,and randomly divided into control group(n=17)and study group(n=17)using the random number method.Patients in control group were treated with sodium hyaluronate eyedrops,and those in study group received additional carbomer gel.The two groups were compared regarding the clinical efficacy and changes in ocular surface damage indicators before and after treatment.Results:The overall effective rate of treatment in the study group was significantly higher than that in the control group(97.05％vs.76.47％,P＜0.05).After 4 weeks of intervention,patients in both groups showed higher tear break-up time(BUT)and Schirmer Ⅰ test(SIT)scores compared to before treatment(P＜0.05).Patients in the study group showed lower cornea fluorescein staining(FL)and ocular surface disease index(OSDI)scores than before treatment(P＜0.05),and those in the control group exhibited a decrease in OSDI scores(P＜0.05).The improvement in BUT,FL,SIT,and OSDI scores after intervention was significantly better in the study group compared to the control group(P＜0.05).Conclusion:Sodium hyaluronate eyedrops plus carbomer ophthalmic gel has significant efficacy in treating TAO with ocular surface damage.Their combined use can enhance the therapeutic effect and ensure the stability of tear film,thereby improving the subjective and objective discomfort symptoms of the observed subjects,which is worthy of clinical recommendation.
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