Differences in ADC values of normal mammary gland in women of different ages and menstrual statuses
Objective:To investigate the differences and clinical significance of apparent diffusion coefficient(ADC)value in normal mammary gland in women of different age and menstrual status.Methods:The data were collected from 332 healthy subjects undergone MRI examination in our hospital for bilateral breasts due to self-perceived"lumps"or discomfort between August 2020 and November 2022.The cases were initially divided into low-age group(n=107),middle-age group(n=114)and high-age group(n=111),and then further classified into menstrual phase(n=49),proliferative phase(n=77),secretory phase(n=94)and postmenopausal phase(n=112)by the different menstrual status.ADC of normal breasts was repeatedly measured while maintaining consistent ROIs in the Siemens post-processing workstation,and the measurements were then averaged to compare differences in breast ADC values among various age groups and menstrual statuses.Results:The ADC values of both left and right normal breasts in the high-age group were significantly lower than those in the middle-age and low-age groups(P＜0.05).There was no statistical difference between the ADC value of the left and right normal breasts among the low,middle and high group(P＞0.05).The ADC values of bilateral normal breasts in the postmenopausal period were significantly lower than those in the menstrual,proliferative,and secretory phases(P＜0.05).There was no significant difference in the ADC values of bilateral normal breasts among menstrual,proliferative,secretory and postmenopausal phases(P＞0.05).Conclusion:ADC values of normal breasts vary a lot in women of different ages and menstrual statuses,therefore,diagnosis of female breast conditions by ADC value should take the difference of baseline ADC value into consideration.
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