Effects of different serum 25-hydroxyvitamin D levels on the brain development of preterm infants
Objective:To observe the effects of different serum 25-hydroxy vitamin D[25(OH)D]levels on the brain development in preterm infants.Methods:A total of 293 preterm infants admitted to and treated in our hospital were included from January 2021 to January 2023.Relevant data of the preterm infants were collected,and serum 25(OH)D levels at 48h after birth were measured.Then the infants with serum 25(OH)D level≥75 nmol/L or＜75 nmol/L were included,respectively,in normal group and in deficiency group.Meanwhile,all preterm infants underwent continuous monitoring of brain activity by amplitude-integrated electroencephalography(aEEG),based on which the actual total scoring was calculated.Finally,the corrected total scores were obtained to evaluate the brain development of the preterm infants according to the Expert Consensus on Clinical Application of Neonatal Amplitude-integrated Electroencephalography(AEEG)by subtracting the average total score of preterm infants of corresponding gestational age from the actual total scores,and Pearson correlation coefficient was used to analyze the correlation of 25(OH)D with the brain development in the preterm infants.Results:The average level of25(OH)D was(69.95±14.16)nmol/Lfor the 293 children,in whom 98 had serum 25(OH)D level ≥75 nmoVL,and 195 had serum 25(OH)D level＜75 nmol/L.The gestational age was older,and the body weight after birth was heavier in normal group than in deficiency group[(33.76±1.92)weeks vs.(32.86±2.35)weeks;(2 115.80±521.37)g vs.(1 965.56±562.41)g,respectively,P＜0.05]The amplitude integrated EEG parameters,sleep-wake cycle(SWC),bandwidth(B)and total score in normal group were higher than those in deficiency group(P＜0.05).After correction,the total score of aEEG was(0.49±1.09)points.Pearson correlation analysis showed that the serum 25(OH)D level was significantly negatively correlated with the total score of aEEG in the preterm infants after correction(r=-0.343,P＜0.05).Conclusion:Serum 25(OH)D is related to the brain development of preterm infants,and monitoring the level of 25(OH)D is helpful to estimate the early brain development of preterm infants.
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