Effects of different doses of rimazolam on the hemodynamics in elderly patients during anesthesia induction
Objective:To investigate the effects of different doses of remazolam on the hemodynamics in elderly patients during induction of anesthesia.Methods:Ninety patients undergoing general anesthesia were included in our hospital from January to December of 2022,and equally randomized to group A,B and C,to which the dose of remazolam was applied by 0.2 mg/kg,0.3 mg/kg and 0.4 mg/kg respectively.Then the anesthetic effect and hemodynamics after anesthesia were compared among groups.Results:Theanesthesia sedation worked the fastest in group C,followed by group B.The difference was significant among the three groups(P<0.05).The stroke volume index for the three groups of patients were decreased sequentially at T0,T1,and T2(P<0.05),and the mean arterial pressure was lower at T1 than at T0 and T2(P<0.05).The cardiac index in patients in group A were higher at T1 than T0(P<0.05),and the cardiac index were lower at T2 than at T1 in the three groups of patients(P<0.05).The heart rate was higher at T2 than at T0and T1 in patients in group A(P<0.05).No significant differences in stroke volume index,heart rate and mean arterial pressure were observed in the three groups after anesthesia induction with different doses(P>0.05),yet the cardiac index were higher in group B than in group A and C at T0(P<0.05),and the cardiac index were higher in group A and B than in group C at T1 and T2(P<0.05).Conclusion:0.3 mg/kg remazolam is recommended for general anesthesia induction in elderly patients,for this dose can not only achieve earlier anesthesia induction,but also make more stable hemodynamics.