The mixed dyeing wastewater was a refractory industrial wastewater due to its large amount, high content of organics and complex composition. The combined process of regulating, ABR and A/O was applied to treat this wastewater. The integrated process of ozonation, BAF, UF, RO and electrodialysis was used to reuse secondary effluent. MVR technology was applied to evaporative crystallization of concentrated water. The running results indicated that the whole process had steady treatment effect and strong resistance to lack loading. The effluent quality could meet the requirements of emission standards, and reuse water quality could fully satisfied the requirements of upstream enterprise.