首页|Guided by the principles of microbiome engineering:Accomplishments and perspectives for environmental use
Guided by the principles of microbiome engineering:Accomplishments and perspectives for environmental use
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维普
Although the accomplishments of microbiome engineering highlight its significance for the targeted manipulation of microbial communities,knowledge and technical gaps still limit the applications of microbiome engineering in biotechnology,especially for environmental use.Addressing the environmental challenges of refractory pollutants and fluctuating environmental conditions requires an adequate understanding of the theoretical achievements and practical applications of microbiome engineering.Here,we review recent cutting-edge studies on microbiome engineering strategies and their classical applications in bioremediation.Moreover,a framework is summarized for combining both top-down and bottom-up approaches in microbiome engineering toward improved applications.A strategy to engineer microbiomes for environmental use,which avoids the build-up of toxic intermediates that pose a risk to human health,is suggested.We anticipate that the highlighted framework and strategy will be beneficial for engineering microbiomes to address difficult environmental challenges such as degrading multiple refractory pollutants and sustain the performance of engineered microbiomes in situ with indigenous microorganisms under fluctuating conditions.
State Key Laboratory of Microbial Metabolism,and School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai,China
Department of Environmental Systems Science,ETH Zürich,Zürich,Switzerland
Department of Environmental Microbiology,ETH Zürich,Eawag,Switzerland
College of Engineering,Peking University,Beijing,China
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National Key R&D Program of ChinaShanghai Excellent Academic Leaders ProgramNational Natural Science Foundation of ChinaNational Natural Science Foundation of China
NETL
NSTL
万方数据
维普
