首页|Gut microbiota research nexus:One Health relationship between human,animal,and environmental resistomes

Gut microbiota research nexus:One Health relationship between human,animal,and environmental resistomes

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The emergence and rapid spread of antimicrobial resistance is of global public health concern.The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes(ARGs).In this review,we describe the reservoirs of gut ARGs and their dynamics in both animals and humans,use the One Health perspective to track the transmission of ARG-containing bacteria between humans,animals,and the environment,and assess the impact of antimicrobial resistance on human health and socioeconomic development.The gut resistome can evolve in an environment subject to various selective pressures,including antibiotic administration and environmental and lifestyle factors(e.g.,diet,age,gender,and living con-ditions),and interventions through probiotics.Strategies to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance.With the help of effective measures taken at the national,local,personal,and intestinal management,it will also result in preventing or minimizing the spread of infectious diseases.This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.

antibioticantimicrobial resistancegut microbiotamodulatory strategiesOne Health

Yuhao Fu、Qingyuan Dou、Kornelia Smalla、Yu Wang、Timothy A.Johnson、Kristian K.Brandt、Zhi Mei、Maoyuan Liao、Syed A.Hashsham、Andreas Sch?ffer、Hauke Smidt、Tong Zhang、Hui Li、Robert Stedtfeld、Hongjie Sheng、Benli Chai、Marko Virta、Xin Jiang、Fang Wang、Yong-Guan Zhu、James M.Tiedje

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State Key Laboratory of Soil and Sustainable Agriculture,Institute of Soil Science,Chinese Academy of Sciences,Nanjing,China

University of Chinese Academy of Sciences,Beijing,China

Julius Kühn Institute(JKI)Federal Research Centre for Cultivated Plants,Braunschweig,Germany

Department of Animal Sciences,Purdue University,West Lafayette,Indiana,USA

Section for Microbial Ecology and Biotechnology,Department of Plant and Environmental Sciences,University of Copenhagen,Frederiksberg C,Denmark

Sino-Danish Center(SDC),Beijing,China

Department of Microbiology,University of Helsinki,Helsinki,Finland

Department of Plant,Soil and Microbial Sciences,Center for Microbial Ecology,Michigan State University,Michigan,USA

Department of Civil and Environmental Engineering,Michigan State University,Michigan,USA

Institute for Environmental Research,RWTH Aachen University,Aachen,Germany

Laboratory of Microbiology,Wageningen University & Research,Wageningen,The Netherlands

Environmental Microbiome Engineering and Biotechnology Laboratory,Center for Environmental Engineering Research,Department of Civil Engineering,The University of Hong Kong,Pokfulam,Hong Kong,China

Institute of Agricultural Resources and Environment,Jiangsu Academy of Agricultural Sciences,Nanjing,China

Key Laboratory of Urban Environment and Health,Institute of Urban Environment,Chinese Academy of Sciences,Xiamen,China

State Key Laboratory of Urban and Regional Ecology,Chinese Academy of Sciences,Beijing,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaInternational Atomic Energy Agency Research ProjectJiangsu Funding Program for Excellent Postdoctoral TalentChina Postdoctoral Science FoundationChinese Academy of Sciences President's International Fellowship InitiativeAcademy of Finland,Innovation Fund DenmarkEuropean Commission Horizon 2020 financed under the ERA-NET Aquatic Pollutants Joint Transnational CallCenter for Health Impacts of Agriculture(CHIA)of Michigan State Universityfellowship of Alexander von HumboldtShennong Young Talents of the Ministry of Agriculture and Rural Affairs,China

4197713742307048D150222022ZB4602023M7335932020DC0005869178SNYCQN006-2022

2023

10.1002/mlf2.12101

微生物(英文)

微生物(英文)

ISSN：
年,卷(期)：2023.2(4)
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