Advances in molecular evolution of coxsackievirus A6 and epidemic of hand,foot and mouth disease
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手足口病(hand,foot and mouth disease,HFMD)是一种可由多种肠道病毒引起的以儿童急性感染为主的全球性传染病.近期,柯萨奇病毒A组6型(coxsackievirus A6,CVA6)引起的典型及非典型HFMD在多个国家及地区发病率明显上升且临床表现多样.而CVA6的分子进化、人群群体免疫屏障的建立等均可影响HFMD的暴发流行及病原谱的变迁.现就CVA6的流行、分子进化与重组、氨基酸变异、结构解析及血清流行病学研究作一概述,旨在为HFMD的防控提供思路.
Hand,foot and mouth disease(HFMD)is a global infectious disease caused by a variety of enteroviruses,which mainly infects children.Recently,the incidence of typical and atypical HFMD caused by coxsackievirus A6(CVA6)has in-creased significantly in many countries and regions with diverse clinical manifestations.The molecular evolution of CVA6 and the establishment of herd immunity barrier can affect the outbreak and change of pathogen spectrum of HFMD.In this review,the epidemiology,molecular evolution and recombination,amino acid variation,structural analysis and seroepidemiol-ogy of CVA6 are reviewed,aiming to provide ideas for the prevention and control of HFMD.
Hand,foot and mouth diseaseCoxsackievirus A6(CVA6)Clinical symptomsMolecular evolutionRecombina-tionStructure analysisAmino acid variationSeroepidemiology
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