Respiratory syncytial virus(RSV)is one of the major causes of severe lower respiratory tract infections in chil-dren under 5 years worldwide,and recurrent infections in the elderly and people with compromised immune systems,cardiac and pulmonary systems can lead to severe illness and even death.The development of safe and effective treatments and pre-ventive vaccines is one of the most scientific and economical means to prevent RSV infection.Although the main target of most current RSV vaccine candidates and antibodies is the pre-fusion F protein,the respiratory syncytial virus G protein is also one of the main protective antigens on the surface of the RSV virus.During RSV infection,G protein affects the host's immune response or causes the development of RSV-related diseases through binding to cell surface receptors.Researches prove that the cysteine-X-X-X-cysteine(CX3C)chemokine motif of G protein plays an important role in immune response and pathogenesis,and characterization analysis shows the G protein may be an important target with great potential for the development of vaccines and antiviral drugs.This article reviews the cell surface receptors associated with RSV G protein,the effect of G protein on the immune response of RSV-infected hosts,and the characteristics of the pathogenic mechanism of G protein in animal studies.
Central conserved domainCX3C motifEosinophiliaPathogenesisChemokine receptorGlycosaminoglycans
NETL
NSTL
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