The Gram-negative opportunistic pathogen Acinetobacter baumannii(AB)has become one of the main causes of nosocomial infections.The mechanisms of drug resistance in AB are far more complicated,among which AdeABC efflux pump is recognized to play an important role.This pump is mediated by a signal transduction system for AB,two component system(TCS).Specifically,TCS AdeRS and BaeSR from AB can regulate the expression of AdeABC efflux pump,showing great potential as AB antibacterial drug targets.This article reviews the research progress of TCS on AdeABC efflux pump regulation and TCS inhibitors.
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