Microneedle arrays have been a promising transdermal vaccination technology that can deliver vaccines subcuta-neously,eliciting potent cellular immune response without damaging nerves and blood vessels.Microneedles(MNs),consis-ting of nanoscale needle-tips and supporting bases,can be broadly classified into several types:solid microneedles(SMNs),coated microneedles(CMNs),dissolving microneedles(DMNs)and so on.Among them,DMNs show a considerable devel-opment prospect.This type of device is made from biodegradable polymers dried in molds,thus has superior drug loading ca-pabilities relative to other platforms.CMNs-based vaccines show advantages of complete antigen delivery without wasting of drugs,as well as no sharp biohazardous waste generated.This article reviews the structure,fabrication materials and prepara-tion methods of DMNs used for vaccine delivery.
Dissolving microneedlesVaccineTransdermal drug deliveryImmunologic adjuvantImmune effect
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