Determination of 21 organophosphate esters and their metabolites in drinking water by automatic solid phase extraction-liquid chromatography-tandem mass spectrometry
OBJECTIVE To establish a method for simultaneous determination of 21 organophosphate esters(OPEs)and their metabolites in drinking water by automatic solid phase extraction-liquid chromatography-tandem mass spectrometry.METHODS The drinking water was purified by automatic solid phase extraction with HLB column,eluted by methanol,determined by liquid chromatography tandem mass spectrometry with ACQUITY UPLC BEH(100 mm×2.1 mm,1.7 μm)column,and quantified by internal standard method.RESULTS The optimized method could simultaneously detect 21 organophosphate esters and their metabolites in drinking water.The detection limit was 0.01-0.24 ng/L,the quantitation limit was 0.03-0.77 ng/L.The recovery range was 57.6％-121.2％and the relative standard deviation is 1.2％-11.1％when the concentration was 0.8-20 ng/L.Senventeen tap water and 30 packaged drinking water collected by the supermarket were measured.The ΣOPEs range was 16.8-177 ng/L,and the Σdi-OPEs range was 0.328-16.3 ng/L,indicating the exposure risk of organophosphates and their metabolites in water.CONCLUSION The pretreatment of the method is simple,automatic and sensitive,and is suitable for simultaneous high-throughput determination of organophosphate esters and their metabolites in large quantities of drinking water.
NETL
NSTL
万方数据
维普
