In order to optimize the layout of electric power material storage,the Apriori algorithm is used to build the optimiza-tion model of electric power material storage.Vaccination strategy is introduced to build an improved Clonal selection algo-rithm.The results show that on the Sphere function and Ackley function,the improved Clonal selection algorithm tends to con-verge after 400 iterations,with fitness values of 10-75 and 10-17.By solving the F function,the improved Clonal selection algo-rithm obtains the optimal solution of 1.03,the average solution of 1.12,the average optimization efficiency is 8.20%,the standard deviation is 0.07,and the optimization efficiency increased is 14.15%.In the classification of materials,the accuracy of the improved Clonal selection algorithm is 94.5%and 89.6%.The improved Clonal selection algorithm optimizes the layout of the storage and improves the efficiency of power material distribution.