In response to the insufficient comprehensiveness of the practical teaching content of the"Python Language Programming"course,the low integration with the actual projects of the discipline,and the decoupling from cutting-edge knowledge and advanced technology,this article designs a teaching reform plan for the course based on the OBE concept.This plan starts from the results and constructs a three-layer system of practical teaching content,establishing a Python case resource library that includes practical application background,multidisciplinary and multi domain problems,and cutting-edge information technology.Through practice,the proposed course reform scheme has improved students'computational thinking,comprehensive application and innovation abilities,and improved learning outcomes.