Objective:To investigate the relationship between serum apolipoprotein A1(ApoA-1)levels dur-ing hospitalization and early post-myocardial infarction heart failure in elderly patients.Method:A retrospective col-lection of 207 elderly patients(≥60 years)diagnosed with acute myocardial infarction in our hospital from January 2020 to April 2021 was conducted.The patients were divided into heart failure group(n=93)and non-heart failure group(n=114)based on the occurrence of heart failure.Differences in clinical baseline data(age,gender,medical history,etc.)and biochemical parameters(lipid profile,renal function,etc.)between the two groups were com-pared.Logistic regression analysis was used to evaluate the correlation between ApoA-1 and early post-myocardial infarction heart failure in elderly patients.ROC curve analysis was performed to assess the predictive efficacy of ApoA-1 and other related indicators for early post-myocardial infarction heart failure in elderly patients.Results:Compared with the non-heart failure group,the heart failure group had significantly lower levels of total cholesterol,high-density lipoprotein cholesterol,and ApoA-1(P＜0.05).Multivariate logistic regression analysis showed that ApoA-1 and NT-proBNP were independently and negatively correlated with the occurrence of early post-myocardial infarction heart failure in elderly patients(P＜0.05).ROC curve analysis revealed that the AUCs of ApoA-1 and NT-proBNP in predicting early post-myocardial infarction heart failure events in elderly patients were 0.624(95％CI:0.547-0.702,P＜0.01)and 0.749(95％CI:0.680-0.819,P＜0.01)respectively,and their predictive effi-cacy significantly improved when combined(AUC=0.780,95％CI:0.714-0.846,P＜0.01).Conclusion:ApoA-1 and NT-proBNP can be used to predict the occurrence of early post-myocardial infarction heart failure in elderly patients,and were independently associated with it.
维普
万方数据
