Correlation of Blood Lactate,HIF-1α and PGE2 Levels with Microcirculatory Function and Cardiac Dysfunction in Patients with Sepsis Accompanied by Heart Failure
Objective:To analysis the relationship between blood lactate,prostaglandin-2(PGE2),hypoxia inducible factor-1α(HIF-1α)and microcirculation and cardiac function in patients with sepsis complicated by acute heart failure.Method:86 patients diagnosed with sepsis and complicated with acute heart failure from March 2020 to February 2023 were set as group A,and another 90 patients who did not experience heart failure in sepsis during the same period were set as group B.The blood lactate,PGE2,and HIF-1α levels of the two groups of patients were measured on the first,third,and fifth day of diagnosis of sepsis.The echocardiographic indicators and microcirculation function parameters between two groups of patients were compared,and the correlation of blood lactate,PGE2 and HIF-1α with cardiac function and microcirculation function was analyzed.Results:Blood lactate,PGE2 and HIF-1αlevels of group A patients at three time points on day 1,day 3,and day 5 were significantly higher than those of group B,and the differences were statistically significant(P＜0.01).Blood lactate,PGE2,and HIF-1 levels in two groups of patients on the third day after diagnosis of sepsis were at peak level.The levels of PPV,PVD,MFI,EDV,ESV,SV,LVEF,CO,FS,and E/A in group A patients were significantly lower than those in group B(P＜0.01).The blood lactate levels in patients with sepsis complicated by acute heart failure were significantly nega-tively correlated with PPV,PVD,MFI,SV,LVEF,E/A(P＜0.05 or P＜0.01).PGE2 levels were significantly negatively correlated with PPV,PVD,MFI,LVEF,FS measurements(P＜0.05 or P＜0.01).There is a signifi-cant negative correlation between HIF-1α and PPV,PVD,MFI,LVEF,CO,and FS measurements(P＜0.01).Conclusion:Blood lactate,PGE2,and HIF-1α levels in patients with sepsis complicated by acute heart failure can significantly increase and is closely related to the patient's heart function damage and microcirculation disorders.
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