摘要
目的:探讨非酒精性脂肪肝(NAFLD)患者血清成纤维细胞生长因子21(FGF21)水平变化及与颈动脉粥样硬化斑块发生的相关性.方法:选取2023-01-2023-09确诊的NAFLD患者131例,根据是否存在颈动脉粥样硬化斑块分为无斑块组(n=59)和斑块组(n=72),选取同期体检健康者39例为对照组.检测所有对象血清尿酸(UA)、低密度脂蛋白胆固醇(LDL-C)、小而密低密度脂蛋白胆固醇(sdLDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)和FGF21水平并比较组间差异.Logistic回归分析FGF21与NAFLD患者颈动脉粥样硬化斑块发生的相关性.结果:与对照组比较,无斑块组和斑块组患者UA、TC、TG、LDL-C、sdLDL-C和FGF21水平均升高,HDL-C水平降低(P＜0.05或P＜0.01);与无斑块组比较,斑块组LDL-C、sdLDL-C和FGF21升高(P＜0.05或P＜0.01).Logistic回归分析显示,在充分调整协变量后,血清FGF21升高与NAFLD患者动脉粥样硬化斑块发生呈正相关.结论:血清FGF21是NAFLD患者颈动脉粥样硬化斑块发生的危险因素.
Abstract
Objective:To explore the correlation between fibroblast growth factor 21(FGF21)and the occur-rence of carotid atherosclerotic plaques in patients with non-alcoholic fatty liver disease(NAFLD).Method:A total of 131 patients diagnosed with NAFLD from January 2023 to September 2023 were selected and divided into the plaque group and the no-plaque group based on the presence or absence of carotid atherosclerotic plaques.Addition-ally,39 healthy individuals undergoing routine check-ups at the same period were chosen as the control group.Ser-um levels of uric acid(UA),low-density lipoprotein cholesterol(LDL-C),small dense low-density lipoprotein cho-lesterol(sdLDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG),total cholesterol(TC),and FGF21 were measured,and differences in these parameters were analyzed.Logistic regression analysis was em-ployed to determine the correlation between serum FGF21 levels and the occurrence of carotid atherosclerotic plaques in NAFLD patients.Results:Compared to the control group,both the no-plaque and plaque groups showed in-creased levels of UA,TC,TG,LDL-C,sdLDL-C,and FGF21,while HDL-C levels were reduced(P＜0.05 or P＜0.01).Compared to the no-plaque group,the plaque group had higher levels of LDL-C,sdLDL-C,and FGF21,with these differences were statistically significant(P＜0.05 or P＜0.01).After adjusting for covariates,logistic regression analysis revealed that increased serum FGF21 levels were positively correlated with the occurrence of ar-terial atherosclerotic plaques in NAFLD patients.Conclusion:Serum FGF21 levels are associated with the occur-rence of carotid atherosclerotic plaques in patients with NAFLD.
维普
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