Patients with type 2 diabetes mellitus(T2DM)have a reduced microbiota that produces short-chain fatty acids(SCFAs)in lower abundance,altered intestinal flora,impaired intestinal barrier function,and ele-vated plasma lipopolysaccharide levels.Dietary fibre positively regulates glucose metabolism and improves obesity by increasing the production of SCFAs by colonic fibre fermentation,which is conducive to the reduction of the inci-dence and progression of T2DM.Thus,the use of dietary fibre intervention has positive clinical significance in the prevention and treatment of T2DM.
关键词
2型糖尿病/膳食纤维/短链脂肪酸/肠道微生物
Key words
Type 2 diabetes/Dietary fiber/Short-chain fatty acids/Gut microbiota
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