Radiotherapy is currently an important treatment for thoracic malignancies,but its associated radi-ation-induced heart disease(RIHD)has become one of the major causes of non-tumour death in patients treated with radiotherapy,severely diminishing its clinical benefit.The pathophysiological mechanisms of RIHD are complex,involving inflammatory damage to endothelial cells,oxidative stress,DNA damage,myocardial fibrosis,and so on.Radiation injury may eventually damage all structures of the heart,including the pericardium,coronary arteries,conduction system,myocardium,and heart valves.Cardiac function should be routinely monitored during radiother-apy in oncology patients in combination with ECG,markers of myocardial injury,and imaging for early detection of RIHD.There are no definitive and effective measures for treatment,and the main strategies include control of risk factors,reduction of radiotherapy dose,and pharmacological treatment.In this article,we review the recent re-search findings on RIHD for clinical reference.
Radiation-induced heart diseaseMalignant tumors of the chestRadiation therapy
维普
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