Objective:To explore the feasibility and clinical value of ultrasound super-resolution imaging(SRI)technology in assessing renal microcirculation in acute kidney injury(AKI)patients.Method:52 patients with sepsis were divided into AKI group(n=32)and without AKI group(control group,n=20).Renal ultrasound and clinical data of all patients were obtained.SonoVue contrast agent(1.5 ml)was injected intravenously through the elbow vein,and Mindray Resona A20 ultrasonic diagnostic system was used to collect dynamic contrast images for 2 min.The time-intensity curve(TIC)of renal perfusion was analyzed.After 15 minutes,CEUS was performed again to obtain the microscopic blood flow map of the kidney.Microvascular density was calculated,and its correla-tion with blood creatinine was analyzed.Results:There were no significant differences in renal morphology between the AKI group and the control group(P＞0.05).The rise time,time to peak,and mean transit time of the renal cortex in the AKI group were all prolonged compared to the control group(all P＜0.01),while the peak intensity and the area under the time-intensity curve were lower than those in the control group(all P＜0.05).The micro-vascular density of the renal cortex in the AKI group was lower than that in the control group(18.09±6.20％vs 45.56±11.88％,P＜0.01),and the microvascular density in the AKI group showed a negative correlation with blood creatinine(r=-0.86,P＜0.01).Conclusion:Ultrasound SRI can effectively assess renal microcirculation in AKI patients.SRI is a new method for non-invasive quantitative evaluation of renal microcirculation.
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