Objective:To investigate changes of the serum level of angiopoietin-like protein 5(ANGPTL5)in coronary artery disease(CAD)patients and explore its relationship with glycometabolism and lipid metabolism.Method:A total of 239 individuals suspected as CAD were enrolled from January 2019 to December 2019.According to the results of coronary angiography,they were classified as CAD group(n=156)and non-CAD group(n=83)respectively.Serum ANGPTL5 levels were detected by enzyme-linked immunosorbent assay.Correlations between serum ANGPTL5 and parameters such as blood lipids,glucose and number of lesion vessels were all evaluated sta-tistically.Results:Serum ANGPTL5 levels in CAD patients were higher than those without CAD(P＜0.01).Mo-reover,serum ANGPTL5 levels were significantly higher in CAD patients with higher lesion vessels,especially the highest in three-vessel group(P＜0.05).Similarly,it was higher in patients with diabetes mellitus or hyperlipi-demia than those without diabetes mellitus or hyperlipidemia(P＜0.05).The ANGPTL5 level was positively cor-related with the levels of FPG(r=0.339,P＜0.01),triglycerides(r=0.354,P＜0.01)and very low density lip-oprotein-cholesterol(r=0.188,P＜0.05).ANGPTL5 was a risk factor for CAD(OR=1.998,95％CI:1.440-2.773,P＜0.01).After the adjustment for confounding factors including sex,age,FPG and blood lipids,patients with higher ANGPTL5 levels still had a higher OR for CAD(OR=1.916,95％CI:1.155-3.177,P＜0.01).Conclusion:Serum ANGPTL5 levels were elevated in CAD patients and positively correlated with the disorder of glycometabolism,lipid metabolism and the number of lesion vessels of CAD.
NETL
NSTL
万方数据
