冠心病患者血清血管紧张素样蛋白5水平变化及临床意义
Expression Level and Clinical Significance of Serum Angiopoietin-like Protein 5 in Coronary Artery Disease
吴星亮 1李君 1吕永楠 1徐红新 1任伟 2蒋学俊 1刘畅 3易欣1
作者信息
- 1. 武汉大学人民医院心内科,武汉 430060;武汉大学心血管病研究所,武汉 430060;心血管病湖北省重点实验室,武汉 430060
- 2. 武汉大学人民医院检验科,武汉 430060
- 3. 阜外华中心血管病医院结构心脏病科,郑州 450000
- 折叠
摘要
目的:分析冠心病患者血清血管生成素样蛋白5(ANGPTL5)水平变化及与冠心病糖脂代谢紊乱的相关性.方法:纳入2019-01-2019-12本院就诊的疑似冠心病患者239例,根据冠脉造影结果分为冠心病组(n=156)和非冠心病组(n=83).酶联免疫吸附试验检测所有患者血清ANGPTL5的表达水平,分析血清ANGPTL5水平与冠心病患者糖脂水平、冠脉病变支数等临床参数的相关性.结果:与非冠心病组相比,冠心病组患者血清ANGPTL5水平明显升高(P＜0.01).随着冠脉病变支数增加,冠心病患者ANGPTL5水平升高,三支病变组水平最高(P＜0.05).合并糖尿病或高脂血症的冠心病患者的血清ANGPTL5水平较未合并糖尿病或高脂血症的冠心病患者明显升高,差异具有统计学意义(P＜0.05).相关性分析显示,冠心病患者血清ANGPTL5水平与空腹血糖(FPG)(r=0.339,P＜0.01)、甘油三酯(TG)(r=0.354,P＜0.01)、极低密度脂蛋白胆固醇(VLDL-C)(r=0.188,P＜0.05)水平均呈正相关.多因素Logistic回归显示ANGPTL5是冠心病的危险因素(OR=1.998,95％CI:1.440-2.773,P＜0.01).校正混杂因素(性别、年龄、空腹血糖和血脂)后血清ANGPTL5水平升高仍是冠心病的危险因素(OR=1.916,95％CI:1.155-3.177,P＜0.01).结论:冠心病患者血清ANGPTL5水平升高,且与冠心病患者糖脂代谢状况和冠脉病变支数有关.
Abstract
Objective:To investigate changes of the serum level of angiopoietin-like protein 5(ANGPTL5)in coronary artery disease(CAD)patients and explore its relationship with glycometabolism and lipid metabolism.Method:A total of 239 individuals suspected as CAD were enrolled from January 2019 to December 2019.According to the results of coronary angiography,they were classified as CAD group(n=156)and non-CAD group(n=83)respectively.Serum ANGPTL5 levels were detected by enzyme-linked immunosorbent assay.Correlations between serum ANGPTL5 and parameters such as blood lipids,glucose and number of lesion vessels were all evaluated sta-tistically.Results:Serum ANGPTL5 levels in CAD patients were higher than those without CAD(P＜0.01).Mo-reover,serum ANGPTL5 levels were significantly higher in CAD patients with higher lesion vessels,especially the highest in three-vessel group(P＜0.05).Similarly,it was higher in patients with diabetes mellitus or hyperlipi-demia than those without diabetes mellitus or hyperlipidemia(P＜0.05).The ANGPTL5 level was positively cor-related with the levels of FPG(r=0.339,P＜0.01),triglycerides(r=0.354,P＜0.01)and very low density lip-oprotein-cholesterol(r=0.188,P＜0.05).ANGPTL5 was a risk factor for CAD(OR=1.998,95％CI:1.440-2.773,P＜0.01).After the adjustment for confounding factors including sex,age,FPG and blood lipids,patients with higher ANGPTL5 levels still had a higher OR for CAD(OR=1.916,95％CI:1.155-3.177,P＜0.01).Conclusion:Serum ANGPTL5 levels were elevated in CAD patients and positively correlated with the disorder of glycometabolism,lipid metabolism and the number of lesion vessels of CAD.
关键词
血管生成素样蛋白5/冠心病/糖代谢/脂代谢/病变支数Key words
ANGPTL5/Coronary artery disease/Glycometabolism/Lipid metabolism/Lesion vessels引用本文复制引用
基金项目
湖北省自然科学重点研发计划(2022BCA051)
河南省医学科技攻关计划省部共建项目(SBGJ202102047)
出版年
2024
NETL
NSTL
万方数据