Objective:To explore the effect of proton pump inhibitor(PPI)combined with vitamin C in pre-venting non-active bleeding after percutaneous coronary intervention(PCI)in patients receiving dual antiplatelet therapy.Method:A prospective study was conducted,and 88 patients who underwent PCI and were at risk of bleeding were randomly divided into a control group and an observation group,with 44 patients in each group.Pa-tients in the control group received oral pantoprazole sodium enteric-coated tablets,while patients in the observation group received oral pantoprazole sodium enteric-coated tablets in combination with vitamin C.The two groups were compared for residual platelet high reactivity rate at 3 days after the procedure,bleeding rate within 1 month after the procedure,severity of gastrointestinal bleeding,stress response before and after treatment,and coagulation function indicators.Results:The observation group had a lower rate of residual platelet high reactivity at 3 days af-ter the procedure and a lower bleeding rate within 1 month after the procedure compared to the control group(both P＜0.05).After treatment,both groups showed a decrease in serum malondialdehyde(MDA)levels,with the ob-servation group had lower levels.Both groups showed an increase in serum superoxide dismutase(SOD)levels,with the observation group had higher levels(both P＜0.05).Compared to before treatment,both groups had shortened prothrombin time(PT)and activated partial thromboplastin time(APTT),with the observation group had shorter times.Plasma fibrinogen(FIB)levels increased in both groups,with the observation group had higher levels(both P＜0.05).There was no significant difference in the overall incidence of adverse reactions such as stent thrombosis,myocardial infarction,arrhythmia,and sudden cardiac death between the two groups(P＞0.05).Con-clusion:The combination of vitamin C and PPI therapy effectively reduces the risk of non-active bleeding in patients receiving dual antiplatelet therapy after PCI.
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