M channels are an important part of the Kv7 family of voltage-gated potassium channels,which are found primarily in the nervous and vascular systems.M channels mediate the M current to stabilize the mem-brane potential and inhibit abnormal discharges,which is important in regulating neuronal excitability and vascular tone.Studies have shown that M channels dysfunction is closely related to various neuropsychical diseases and cardi-ovascular diseases and is a key target for drug therapy.In this review,we provide an overview of the structural het-erogeneity and function of M channels in different tissues,and review their roles in the development and progression of neuropsychical diseases and cardiovascular diseases such as epilepsy,Alzheimer's disease,depression,hyperten-sion,coronary artery disease,and pulmonary arterial hypertension,offering new perspectives and target for the treatment of these diseases.
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