M通道与神经精神疾病和心血管疾病研究进展
Advance in M Channel and Neuropsychical Diseases and Cardiovascular Diseases
彭锦强 1刘育1
作者信息
- 1. 武汉大学人民医院心内科,武汉 430060;武汉大学心血管病研究所,武汉 430060;心血管病湖北省重点实验室,武汉 430060
- 折叠
摘要
M通道是电压门控钾通道Kv7家族的重要组成部分,主要分布在神经系统和血管系统中.M通道介导M电流(Im),稳定细胞膜电位和抑制异常放电,在调节神经元兴奋性和血管张力方面发挥重要作用.研究显示,M通道功能异常与神经精神疾病和心血管疾病存在密切关系,是药物治疗的关键靶点.本文对M通道在不同组织中结构异质性和功能进行概述,并综述其在癫痫、阿尔茨海默病、抑郁症、高血压、冠状动脉疾病、肺动脉高压等神经精神疾病和心血管疾病发生发展中的作用,为疾病治疗提供新视角和靶点.
Abstract
M channels are an important part of the Kv7 family of voltage-gated potassium channels,which are found primarily in the nervous and vascular systems.M channels mediate the M current to stabilize the mem-brane potential and inhibit abnormal discharges,which is important in regulating neuronal excitability and vascular tone.Studies have shown that M channels dysfunction is closely related to various neuropsychical diseases and cardi-ovascular diseases and is a key target for drug therapy.In this review,we provide an overview of the structural het-erogeneity and function of M channels in different tissues,and review their roles in the development and progression of neuropsychical diseases and cardiovascular diseases such as epilepsy,Alzheimer's disease,depression,hyperten-sion,coronary artery disease,and pulmonary arterial hypertension,offering new perspectives and target for the treatment of these diseases.
关键词
M通道/神经元/血管张力/疾病靶点Key words
M-channels/Neuron/Vascular tone/Disease target引用本文复制引用
基金项目
国家自然科学基金面上项目(82270318)
出版年
2024
NETL
NSTL
万方数据