载脂蛋白在视网膜疾病中的作用机制研究进展
Advances of the Mechanism of Apolipoproteins in Retinal Diseases
万宇薇 1陈婷 1肖璇 1杨安怀1
作者信息
- 1. 武汉大学人民医院眼科中心,武汉 430060
- 折叠
摘要
载脂蛋白可以通过调节脂质运输实现视网膜脂质代谢平衡,载脂蛋白水平失调、缺失、突变会导致眼部内环境脂质代谢失衡,引起视网膜慢性炎症、脂质沉积等病理改变,诱导视网膜疾病的发生发展.在不同视网膜疾病中研究载脂蛋白家族的功能具有重要意义.
Abstract
Apolipoproteins can maintain retinal lipid homeostatic balance by regulating lipoprotein transporta-tion.And maladjusted apolipoprotein levels will result in pathological retinal changes such as chronic inflammation,and lipid deposition,then contribute to the onset and development of retinal diseases.Therefore,it is of great sig-nificance to explore the functions of Apolipoproteins in multiple retinal diseases.Starting from different subtypes of the apolipoprotein family,this paper summarized the advanced physiological function of apolipoproteins and their roles in the pathogenesis of retinal diseases.
关键词
载脂蛋白家族/脂质代谢/视网膜疾病Key words
Apolipoproteins/Lipid metabolism/Retinal diseases引用本文复制引用
基金项目
湖北省重点研发计划项目(2022BCA009)
出版年
2024
NETL
NSTL
万方数据