Objective:To investigate the relationship between serum homocysteine(Hcy),Delta like ligand 4(DLL4),serum uric acid(SUA)and glucose lipid metabolism,insulin resistance(HOMA-IR)in patients with dia-betes retinopathy.Method:68 patients with diabetes retinopathy(DR group)from January 2021 to January 2024,and 130 patients with simple diabetes(diabetes group)and 100 healthy people(health group)were selected.The differences in Hcy,DLL4,SUA,fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),HOMA-IR,and patients with different degrees of retinopathy in each group were compared.Results:The FBG,HbA1,HOMA-IR,Hcy,DLL4 and SUA in DR group were significantly higher than those in diabetes group and healthy group(P＜0.05).The Hey,DLL4,and SUA of patients with stage Ⅲ-IV retinopathy were significantly higher than those of patients with stage I-Ⅱ retinopathy(P＜0.05).Hcy,DLL4,SUA were positively correlated with FBG,HbA1c,and HOMA-IR(P＜0.05).Conclusion:The serum Hcy,DLL4 and SUA levels in patients with diabetes retinopathy increase,and might be related to the severity of the disease.
Diabetes retinopathyDelta like ligand 4Insulin resistance level
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