Effects of Transcranial Direct-current Stimulation and Cognitive Training on Cognitive Function Re-covery in Patients with Cognitive Impairment after Cerebral Infarction
Objective:To analyze the effects of transcranial direct current stimulation combined with virtual reality cognitive exercises on cerebral blood flow and neurological functions in patients with cognitive impairments following a stroke.Method:A total of 120 patients with poststroke cognitive dysfunction were selected and divided into control group(n=60)and study group(n=60).After all patients were treated with conventional therapy,the control group received virtual reality cognitive training,and the study group received virtual reality cognitive training with tDCS.The cognitive function between both groups(assessed by LOTCA cognitive rating scale),P300 latency and amplitude(monitored by MK-15 ampere evoked potential system),cerebral blood flow circulation(monitored by color Doppler ultrasound),neurological function(assessed by NIHSS score),and the incidence of adverse reac-tions during treatment were recorded.Results:LOTCA score(total score and each dimension score),P300 latency and amplitude,mean blood flow,mean velocity,vascular resistance,NIHSS score,CNS-specific protein,neuron-specific enolase in both two groups before treatment were no differences(P＞0.05).The LOTCA score,ampli-tude,mean blood flow and mean velocity were increased compared with those before treatment,and the study group was higher than the control group(P＜0.05).P300 latency,vascular resistance,NIHSS,CNS specific enolase were decreased compared to pre-treatment,which were even lower in the study group(P＜0.05).The occurrence of adverse reactions did not vary significantly between the two groups(P＞0.05).Conclusion:tDCS combined with virtual reality cognitive training may be an effective method to improve cognitive function and neurological function in patients after stroke,and does not increase the incidence of adverse reactions in patients,with a high safety pro-file.
Transconal cranial direct current stimulationStrokeCognitive impairmentNerve function
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