摘要
目的:分析非酒精性脂肪肝患者血清Toll样受体4(TLR4)、白介素-17(IL-17)和白介素-23(IL-23)水平及与几种常见肠道菌的相关性.方法:回顾性收集2020-01-2022-06本院收治的128例非酒精性脂肪肝患者作为非酒精性脂肪肝组,选取同期在我院进行体检的134例健康体检者作为健康对照组,比较两组血清TLR4、IL-17、IL-23水平及几种常见肠道菌的差异,采用Pearson相关分析非酒精性脂肪肝患者血清TLR4、IL-17、IL-23水平与同几种常见肠道菌的相关性.结果:非酒精性脂肪肝组患者血清TLR4、IL-17、IL-23水平、肠杆菌、肠球菌水平均高于健康对照组(P＜0.05),双歧杆菌、乳酸杆菌、拟杆菌、双歧杆菌/肠杆菌(B/E)水平均低于健康对照组.Pearson分析结果显示,非酒精性脂肪肝患者血清TLR4、IL-17、IL-23水平与双歧杆菌、乳酸杆菌、拟杆菌、B/E水平呈显著负相关(P＜0.05),与肠杆菌、肠球菌呈显著正相关(P＜0.05).结论:非酒精性脂肪肝患者血清TLR4、IL-17、IL-23水平异常升高与双歧杆菌、乳酸杆菌、拟杆菌水平显著相关,调节患者肠道菌群有助于改善机体炎症反应.
Abstract
Objective:To analyze the expression levels of serum Toll-like receptor 4(TLR4),interleukin-17(IL-17)and interleukin-23(IL-23)in patients with non-alcoholic fatty liver disease(NAFLD)and their correlation with several comman intestinal bacteria.Method:128 patients with non-alcoholic fatty liver disease from January 2020 to June 2022 were retrospectively collected as the non-alcoholic fatty liver disease group,and the 134 healthy people who underwent physical examination in our hospital during the same period were selected as the healthy con-trol group.The general information and biochemical indicators of the two groups were analyzed,and the levels of serum TLR4,IL-17,IL-23 and intestinal flora were compared between the two groups.Pearson analysis was used to analyze the correlation between levels of serum TLR4,IL-17,IL-23 and intestinal microbiota in patients with non-alcoholic fatty liver disease.Results:The levels of serum TLR4,IL-17,IL-23,and Enterobacter and Entero-coccus in the non-alcoholic fatty liver group were higher than those in the healthy control group(P＜0.05),and the levels of Bifidobacterium,Lactobacillus,Bacteroides,Staphylococcus and Bifidobacteria/Enterobacteria(B/E)were lower than those in the healthy control group(P＜0.05).Pearson analysis showed that the serum levels of TLR4,IL-17 and IL-23 in patients with non-alcoholic fatty liver disease were negatively correlated with the levels of Bifidobacterium,Lactobacillus,Bacteroides,Staphylococcus and B/E(P＜0.05),which were positively correlated with Enterobacteria and Enterococcus(P＜0.05).Conclusion:The serum levels of TLR4,IL-17 and IL-23 in pa-tients with non-alcoholic fatty liver disease were abnormally elevated,which were significantly correlated with the level of intestinal flora.
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万方数据