Objective:To analyze the expression levels of serum Toll-like receptor 4(TLR4),interleukin-17(IL-17)and interleukin-23(IL-23)in patients with non-alcoholic fatty liver disease(NAFLD)and their correlation with several comman intestinal bacteria.Method:128 patients with non-alcoholic fatty liver disease from January 2020 to June 2022 were retrospectively collected as the non-alcoholic fatty liver disease group,and the 134 healthy people who underwent physical examination in our hospital during the same period were selected as the healthy con-trol group.The general information and biochemical indicators of the two groups were analyzed,and the levels of serum TLR4,IL-17,IL-23 and intestinal flora were compared between the two groups.Pearson analysis was used to analyze the correlation between levels of serum TLR4,IL-17,IL-23 and intestinal microbiota in patients with non-alcoholic fatty liver disease.Results:The levels of serum TLR4,IL-17,IL-23,and Enterobacter and Entero-coccus in the non-alcoholic fatty liver group were higher than those in the healthy control group(P＜0.05),and the levels of Bifidobacterium,Lactobacillus,Bacteroides,Staphylococcus and Bifidobacteria/Enterobacteria(B/E)were lower than those in the healthy control group(P＜0.05).Pearson analysis showed that the serum levels of TLR4,IL-17 and IL-23 in patients with non-alcoholic fatty liver disease were negatively correlated with the levels of Bifidobacterium,Lactobacillus,Bacteroides,Staphylococcus and B/E(P＜0.05),which were positively correlated with Enterobacteria and Enterococcus(P＜0.05).Conclusion:The serum levels of TLR4,IL-17 and IL-23 in pa-tients with non-alcoholic fatty liver disease were abnormally elevated,which were significantly correlated with the level of intestinal flora.
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